Our interests in the field of pharmacokinetics involve, mostly, the absorption and metabolism processes that have an impact on the bioavailability of drugs and prodrugs.

We are focused in understanding the fundamental basis behind these processes, developing in vitro models to study them, developing strategies to overcome barriers to drug action and to improve drug like properties.

To achieve these goals, our expertise in pharmaceutical and analytical chemistry is complemented with that of several groups from iBET, ITQB-FCT and other universities. Working in collaboration with partners from different research fields, like biotechnology, cell line engineering, protein production and crystallography, among others, we are able to undertake the full path that brings theoretical concepts into practice:

- We use the knowledge on enzyme function and activity to close the gap between in vivo performance and that of an in vitro cell model.

- We learn more about the structure and activity of an enzyme, by studying it in different environments through different techniques ranging from biochemistry to crystallography.

- We construct a permeable prodrug to take an impermeable potent in vitro inhibitor into the brain.

- We develop new analytical in vitro methods for studying biological samples in small scale or to improve  bio-representativity.

- We use our methodologies to evaluate the presence of bioactive ingredients in natural matrices.

Our vision is to provide the industry and the academy with new and improved tools to design new drugs and make old drugs better.

An infrastructure of:

Group Leader

Ana Luísa Simplício

Auxiliary investigator

PhD in Pharmaceutical Chemistry, Trinity College Dublin, Ireland, 2004


Instituto de Tecnologia Química e Biológica
Universidade Nova de Lisboa
Av. da República, Apartado 127
2781-901 Oeiras, Portugal

Telephone: +351214469741
FAX: +351214421161


E-mail: anas@itqb.unl.pt