​Peered reviewed publications

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Lamego J, Cunha B, Peixoto C, Sousa MF, Alves PM, Simplício AL, Coroadinha AS. (2012) Carboxylesterase 2 production and characterization in human cells: new insights into enzyme oligomerization and activity. Appl Microbiol Biotechnol. 

 

Mendes A, Branco LC, Morais C, Simplício AL (2012)  Electroosmotic flow modulation in capillary electrophoresis by organic cations from ionic liquids, Electrophoresis. 33(7):1182-90.







Lamego J, Coroadinha AS, Simplício AL. (2011) Detection and Quantification of Carboxylesterase 2 Activity by Capillary Electrophoresis. Anal. Chem. 83(3):881-887.
 

Torres, V. M., Posa, M., Srdjenovic, B., & Simplício, A. L. (2011) Solubilization of fullerene C60 in micellar solutions of different solubilizers. Colloids and Surfaces B: Biointerfaces. 82(1):46-53.







Djordjevic Milic V,Srdjenovic B , Jacevic V, Dragojevic Simic V, Djordjevic A and Simplício AL. (2010) "Fullerenol C60(OH)24 successfully prevents doxorubicin induced acute cardiotoxicity in rats",  Pharm. Reports, vol. 62, no. 4, 707-718.
 

Moura, J., & Simplício, A. L. (2010). Electrophoretically mediated microanalysis for the evaluation of interspecies variation in cholinesterase metabolism. Electrophoresis, 31(14), 2374-2376.
 

Serra, H., Bronze, M. d. R., & Simplício, A. L. (2010). Simultaneous determination of clopidogrel and its carboxylic acid metabolite by capillary electrophoresis. J. Chrom.  B: Analytical Technologies in the Biomedical and Life Sciences, 878(19), 1480-1486.




 

Perry, M. J., Mendes, E., Simplício, A. L., Coelho, A., Soares, R. V., Iley, J., et al. (2009). Dopamine- and tyramine-based derivatives of triazenes: Activation by tyrosinase and implications for prodrug design. Eur. J. Med. Chem., 44(8), 3228-3234.
 

Márquez Ruiz, J. F., Radics, G., Windle, H., Serra, H. O., Simplício, A. L., Kedziora, K., et al. (2009). Design, synthesis, and pharmacological effects of a cyclization-activated steroid prodrug for colon targeting in inflammatory bowel disease. J. Med. Chem., 52(10), 3205-3211.
 

Sampaio de Sousa, A. R., Silva, R., Tay, F. H., Simplício, A. L., Kazarian, S. G., & Duarte, C. M. M. (2009). Solubility enhancement of trans-chalcone using lipid carriers and supercritical CO2 processing. J.Supercritical Fluids, 48(2), 120-125.




 

Gamelas, C. A., Lourenço, T., da Costa, A. P., Simplício, A. L., Royo, B., & Romão, C. C. (2008). Selective and mild oxidation of sulfides to sulfoxides or sulfones using H2O2 and Cp′Mo(CO)3Cl as catalysts. Tetrah. Letters, 49(32), 4708-4712.
 

Mellado, M. C. M., Franco, C., Coelho, A., Alves, P. M., & Simplício, A. L. (2008). Sodium dodecyl sulfate-capillary gel electrophoresis analysis of rotavirus-like particles. J. Chrom. A, 1192(1), 166-172.
 

Duarte, A. R. C., Simplicio, A. L., Vega-González, A., Subra-Paternault, P., Coimbra, P., Gil, M. H., et al. (2008). Impregnation of an intraocular lens for ophthalmic drug delivery. Current Drug Delivery, 5(2), 102-107.
 

Serra, H., Mendes, T., Bronze, M. R., & Simplício, A. L. (2008). Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones. Bioorg. Med. Chem., 16(7), 4009-4018.
 

Simplício, A. L., Clancy, J. M., & Gilmer, J. F. (2008). Prodrugs for amines. Molecules, 13(3), 519-547.




 

Sampaio de Sousa, A. R., Simplício, A. L., de Sousa, H. C., & Duarte, C. M. M. (2007). Preparation of glyceryl monostearate-based particles by PGSS®-application to caffeine. J. Supercritical Fluids, 43(1), 120-125.
 

Duarte, A. R. C., Simplicio, A. L., Vega-González, A., Subra-Paternault, P., Coimbra, P., Gil, M. H., et al. (2007). Supercritical fluid impregnation of a biocompatible polymer for ophthalmic drug delivery. J. Supercritical Fluids, 42(3 SPEC. ISS.), 373-377.
 

Simplício, A. L., Clancy, J. M., & Gilmer, J. F. (2007). β-Aminoketones as prodrugs with pH-controlled activation. Int. J. Pharmaceutics, 336(2), 208-214.




 

Duarte, A. R. C., Casimiro, T., Aguiar-Ricardo, A., Simplício, A. L., & Duarte, C. M. M. (2006). Supercritical fluid polymerisation and impregnation of molecularly imprinted polymers for drug delivery. J. Supercritical Fluids, 39(1), 102-106.
 

Simplício, A. L., Matias, P., Gilmer, J. F., & Clancy, J. M. (2006). Chiral separation and identification of β-aminoketones of pharmacological interest by high performance liquid chromatography and capillary electrophoresis. J. Chrom. A, 1120(1-2), 89-93.
 

Duarte, A. R. C., Gordillo, M. D., Cardoso, M. M., Simplício, A. L., & Duarte, C. M. M. (2006). Preparation of ethyl cellulose/methyl cellulose blends by supercritical antisolvent precipitation. Int. J. Pharmaceutics, 311(1-2), 50-54.
 

Duarte, A. R. C., Costa, M. S., Simplício, A. L., Cardoso, M. M., & Duarte, C. M. M. (2006). Preparation of controlled release microspheres using supercritical fluid technology for delivery of anti-inflammatory drugs. Int. J. Pharmaceutics, 308(1-2), 168-174.




 

Gilmer, J. F., Simplício, A. L., & Clancy, J. M. (2005). A new amino-masking group capable of pH-triggered amino-drug release. Eur. J.Pharm. Sci., 24(4), 315-323.




 

Simplício, A. L., Gilmer, J. F., Frankish, N., Sheridan, H., Walsh, J. J., & Clancy, J. M. (2004). Ionisation characteristics and elimination rates of some aminoindanones determined by capillary electrophoresis. J.Chrom. A, 1045(1-2), 233-238.



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Simplício, A. L., & Vilas Boas, L. (1999). Validation of a solid-phase microextraction method for the determination of organophosphorus pesticides in fruits and fruit juice. J. Chrom. A, 833(1), 35-42.